About RamanProSeq

RamanProSeq aims to develop a label-free optical single-molecule protein sequencing technology capable of reading protein primary sequence at single-amino-acid resolution with high accuracy. The project will be based on the partners' approaches: ultrafast Raman spectroscopy with 1 microsecond time resolution^[1] and plasmonic nanopore-enhanced Raman sensors that have demonstrated single-molecule identification of 20 proteogenic amino acids^[2], their post-translational modifications^[3,4] and discrimination of single amino acid residues within single peptides^[5]. The proposed technology consists of 5 work packages (WPs) below. If successfully achieved, the RamanProSeq will revolutionize the field of proteomics towards personalized medicine and early diagnosis of diseases.